Commit 19352aaf by Mustafa Tekpinar

Modified README.

parent 9373675a
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# PRESCOTT: Population awaRe Epistatic and StruCtural mOdel of muTational effecTs
## Introduction
PRESCOTT is a program predicting mutational effects of a protein based on population, evolutionary and structural information.
It can calculate effects of single point mutations and multiple point mutations.
PRESCOTT is a package predicting mutational effects in a protein based on population, evolutionary and structural information.
It is made up of two main programs: escott and prescott.
ESCOTT can calculate effects of single point mutations and multiple point mutations. On the other hand, PRESCOTT incorporates
population frequencies into ESCOTT predictions. Therefore, you need to run ESCOTT first to have predictions of mutational effects.
We recommend using PRESCOTT via our web site or our docker image.
## Input Data Requirements
PRESCOTT requires two files:
ESCOTT requires two files:
* a multiple sequence alignment (MSA) file in fasta format (mandatory):
Your query protein must be the first sequence in the fasta file. In addition, the query sequence should not contain any gaps.
......@@ -40,7 +43,7 @@ A quick help can be accessed by typing
escott --help
```
By default, GEMME will predict the effect of all possible single mutations at all positions in the
By default, ESCOTT will predict the effect of all possible single mutations at all positions in the
query sequence. Alternatively, a set of single or multiple mutations can be given with the option -m.
Eachline of the file should contain a mutation (e.g. D136R) or combination of mutations separated
by commas (or colons) and ordered according to their positions in the sequence (e.g. D136R,V271A).
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