Skip to content
Projects
Groups
Snippets
Help
This project
Loading...
Sign in / Register
Toggle navigation
P
PRESCOTT
Overview
Overview
Details
Activity
Cycle Analytics
Repository
Repository
Files
Commits
Branches
Tags
Contributors
Graph
Compare
Charts
Issues
0
Issues
0
List
Board
Labels
Milestones
Merge Requests
0
Merge Requests
0
CI / CD
CI / CD
Pipelines
Jobs
Schedules
Charts
Wiki
Wiki
Snippets
Snippets
Members
Members
Collapse sidebar
Close sidebar
Activity
Graph
Charts
Create a new issue
Jobs
Commits
Issue Boards
Open sidebar
Mustafa Tekpinar
PRESCOTT
Commits
f98b9cb1
Commit
f98b9cb1
authored
Oct 04, 2023
by
Mustafa Tekpinar
Browse files
Options
Browse Files
Download
Email Patches
Plain Diff
Updated the Dockerfile for scikit-learn in prescott.py.
parent
50abe3b4
Show whitespace changes
Inline
Side-by-side
Showing
2 changed files
with
3 additions
and
12 deletions
+3
-12
Dockerfile
Dockerfile
+1
-0
README.md
README.md
+2
-12
No files found.
Dockerfile
View file @
f98b9cb1
...
...
@@ -78,6 +78,7 @@ RUN rm -f hhsuite-3.3.0-AVX2-Linux.tar.gz
WORKDIR
/home/tekpinar/research/lcqb
RUN
sed
-i
s#/home/tekpinar/research/lcqb/JET2/matrix#/usr/local/JET2/matrix#g ./PRESCOTT/prescott/default.conf
RUN
sed
-i
s#/home/tekpinar/research/lcqb/naccess2.1.1/naccess#/usr/local/naccess2.1.1/naccess#g ./PRESCOTT/prescott/default.conf
RUN
pip3 install scikit-learn
RUN
pip3 install ./PRESCOTT/
RUN
pip3 install
-e
./demust/
...
...
README.md
View file @
f98b9cb1
...
...
@@ -54,17 +54,7 @@ escott --help
By default, ESCOTT will predict the effect of all possible single mutations at all positions in the
query sequence. Alternatively, a set of single or multiple mutations can be given with the option -m.
Each line of the file should contain a mutation (e.g. D136R) or combination of mutations separated
by commas (or colons) and ordered according to their positions in the sequence (e.g. D136R,V271A).
GEMME calls JET2 to compute evolutionary conservation levels. By default, JET2 will retrieve a set
of sequences related to the query, independent from the input set, according to specific criteria.
The retrieval method used in JET2 is PSI-BLAST, which can perform the search either locally (by
default) or remotely (-r server). Alternatively, the user can provide her/his own psiblast file
(-r input-b pFile) or her/his own multiple sequence alignment in FASTA format (-r input -f fFile).
JET is run in its iterative mode, iJET, 10 times and the final conservation levels are the maxium
values obtained over the 10 iterations.
JET2 configuration file is: default.conf.
JET2 output file is: myProt_jet.res.
by colons and ordered according to their positions in the sequence (e.g. D136R,V271A).
### Running the prescott program
A quick help can be accessed by typing
...
...
@@ -77,7 +67,7 @@ prescott -e ../data/MLH1_normPred_evolCombi.txt -g ../data/gnomAD_v2.1.1_MLH1_HU
```
The most important output is prescott-scores.txt file, which produces frequecy modified scores for the mutations.
Please note that the example input files are in the data directory of this repository.
Please note that the example input files
for prescott
are in the data directory of this repository.
...
...
Write
Preview
Markdown
is supported
0%
Try again
or
attach a new file
Attach a file
Cancel
You are about to add
0
people
to the discussion. Proceed with caution.
Finish editing this message first!
Cancel
Please
register
or
sign in
to comment